One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects.

Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects.

OBJECTIVE Past studies of cigarette smoking as a contributor to orofacial clefts and neural tube defects (NTDs) used self-reports of smoke exposures. We have correlated measurements of cotinine (a nicotine metabolite) in mid-pregnancy sera with clefts and NTDs. STUDY DESIGN From a repository of >180 000 mid-pregnancy serum specimens collected in California from 2003 to 2005 and linked to deli...

Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.

How folate reduces the risks of congenital anomalies is unknown. The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1). Using data from a California case-control study (1987-1989 births), the authors investigated whether the risks of orofacial clefts or conotruncal heart defects were influenced by a polymorphism of infant RFC1 or by an interaction betwe...

Ambient air pollution and risk of birth defects in Southern California.

The authors evaluated the effect of air pollution on the occurrence of birth defects ascertained by the California Birth Defects Monitoring Program in neonates and fetuses delivered in southern California in 1987-1993. By using measurements from ambient monitoring stations of carbon monoxide (CO), nitrogen dioxide, ozone, and particulate matter <10 microm in aerodynamic diameter, they calculate...

New Insight from Using Spatiotemporal Image Correlation in Prenatal Screening of Fetal Conotruncal Defects

I-19: Risks of Multiple Pregnancy, Preterm

Advances in treating infertile couples by assisted reproductive technologies (ART) over more than three decades have greatly improved the chances of better outcomes. While twinning and higher order multiple birth rates are still high in most countries, lower rates have sometimes been achieved by single-embryo transfer. Multiple preg- Abstracts of the 12th Royan International Congress on Reprodu...